Parsing hippocampal ensembles and acting upon their retrieval
Thursday 17 May @ 4.30pm – 6pm (Le Gros Clark Lecture Theatre, Le Gros Clark Building, Department of Physiology, Anatomy and Genetics)
We’re proud to host Professor David Dupret from the University of Oxford on Thursday May 17th at 4.30pm in the Le Gros Clark Lecture Theatre, Le Gros Clark Building, Department of Physiology, Anatomy and Genetics. After the talk we will go to the Eagle & Child for some food and drinks. Feel free to join!
Hippocampal neuronal activity, described in terms of spatio-temporally organised spike discharge and rhythmic fluctuations of the local field potentials, supports information processing with relevance to memory. However, the circuit-level mechanisms that momentarily define the acquisition, the consolidation or the retrieval of mnemonic information remain somewhat elusive. In this talk, I will present novel findings describing how spectral components nested in individual cycles of the theta-band (4–12Hz) oscillations report transient hippocampal operating modes with complementary mnemonic roles. I will then share some recent work that uncover a circuit motif embedded in the nucleus accumbens that enables the behavioural readout of a hippocampal memory representation. Altogether, these data further highlight how fine-grained neuronal dynamics in the hippocampus and connected circuits promote behaviourally-effective memory.