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New imaging tools to decipher neural network dysfunction underlying cognitive deficits in epilepsy
February 9 @ 17:00 - 19:00
Talk with Dr Peyman Golshani
Date: February 9, 2021 5 PM BST, pub chat at 6 PM BST
Abstract: Temporal lobe epilepsy is associated with memory deficits but the circuit mechanisms underlying these cognitive disabilities are not understood. We used electrophysiological recordings, open-source wire-free miniaturized microscopy and computational modelling to probe these deficits in a model of temporal lobe epilepsy. We find desynchronization of dentate gyrus interneurons with CA1 interneurons during theta oscillations and a loss of precision and stability of place fields. We also find that emergence of place cell dysfunction is delayed, providing a potential temporal window for treatments. Computation modelling shows that desynchronization rather than interneuron cell loss can drive place cell dysfunction. Future studies will uncover cell types driving these changes and transcriptional changes that may be driving dysfunction. I will also discuss new miniaturized microscopy tools, including wire-free, large-field-of view and miniaturized microscopes integrated with high channel count electrophysiology recordings.
Instructions on how to join the talk will be circulated tomorrow on this mailing list.