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Seminar: Dr Athena Akrami
April 29 @ 16:00 - 17:00
Sensory History in Perceptual Decision Making and Working Memory Tasks
Monday 29 April, 4pm at the Sherrington Library, Sherrington Building, Oxford
The Cortex Club is excited to present Athena Akrami, group leader at the UCL Sainsbury Wellcome Centre, who will be talking to us about her research on rat Parametric Working Memory and the role of the posterior parietal cortex. Please join us on April 29th, at the Sherrington Library, located in the Sherrington Building of the Department of Physiology, Anatomy and Genetics, Parks Road, Oxford.
Dr Athena Akrami has kindly agreed to meet students and staff individually. If you would like to arrange a meeting please contact Diego under: diego.asua [at] bnc.ox.ac.uk
Please also join us at the pub after the talk to which everybody is welcome!
Earlier proposals that PPC supports working memory predict that optogenetic silencing of the PPC would lead to a behavioral impairment in our working memory task. Contrary to this prediction, silencing PPC produced a significant performance improvement. Quantitative analyses of behavior revealed that this improvement was due to the selective reduction of the effects of prior sensory stimuli. Electrophysiological recordings showed that PPC neurons carried far more information about sensory stimuli of previous trials than about stimuli of the current trial. Furthermore, an increase in the amount of this information was associated with greater behavioral effects of sensory history, suggesting a tight link between behavior and PPC representations of stimulus history. Lastly, encoding of the sensory history in PPC was contrasted with striatum and frontal pre-motor areas in a series of decision making tasks. Together, the data reveal the PPC as a causally necessary and important node in the representation and use of prior sensory stimulus information.