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Seminar: A/ Professor Denise Cai
June 7, 2019 @ 16:00 - 17:00
Linking Memories Across Time
Friday 7 June, 4pm at the Sherrington Library, DPAG Sherrington Building, Oxford
The Cortex Club is delighted to host Assistant Professor Denise Cai from the Mount Sinai, New York, who will be talking to us about her work on hippocampal networks link memories. Please join us on June 7th, at the Sherrington Library, located in the Sherrington Building of the Department of Physiology, Anatomy and Genetics, Parks Road, Oxford.
A/ Prof. Denise Cai has kindly agreed to meet students and staff individually. If you would like to arrange a meeting please contact Tai-Ying Lee at tai-ying.lee [at] dpag.ox.ac.uk.
Please also join us at the pub after the talk, to which everybody is welcome. Register at https://forms.gle/dx8aScGdEjHo25rb7
The compilation of memories, collected and aggregated across a lifetime defines our human experience. My lab is interested in dissecting how memories are stored, updated, integrated and retrieved across a lifetime. Recent studies suggest that a shared neural ensemble may link distinct memories encoded close in time. Using in vivo calcium imaging (with open-source Miniscopes in freely behaving mice), TetTag transgenic system, chemogenetics, electrophysiology and novel behavioral designs, we tested how hippocampal networks temporally link memories. Multiple convergent findings suggest that contextual memories encoded close in time are linked by directing storage into overlapping hippocampal ensembles, such that the recall of one memory can trigger the recall of another temporally-related memory. Alteration of this process (e.g. during aging, PTSD, etc) affect the temporal structure of memories, thus impairing efficient recall of related information.