Loading Events

« All Events

  • This event has passed.

Seminar: Dr Edward Bartlett

November 22 @ 2:00 pm - 3:00 pm

Paribas or Bury Pa? – Age-related changes in the neural representations of voice onset time in the inferior colliculus
Wednesday 22 November @ 2pm3pm (Sherrington Room, DPAG)

We are pleased to be co-hosting Dr Edward Bartlett from Purdue University on Wednesday 22nd November 2:00 – 3:00 pm (please note the unusual time) in the Sherrington room, DPAG.

All students and junior researchers are invited to a Q&A session (sandwich lunch provided) prior to the talk 12:45 – 1:45 pm in the OCGF seminar room (accessible via the Sherrington building). If you would like to attend the students’ session, please RSVP to cortex.club [at] studentclubs.ox.ac.uk by Tuesday 21st November.

Abstract
The inferior colliculus (IC) integrates a variety of inputs to perform spectrotemporal processing in the primary auditory pathway, including temporal to rate transformations. The temporal to rate transformations occurring in the IC make it important to understand how the auditory pathway is able to adapt to changes in hearing abilities, such as due to aging or noise-induced hearing loss. In this study, we used consonant-vowel sounds that varied in voice onset time (VOT) (ba to pa), either with tokens or the envelopes of those tokens to modulate a noise carrier. Synchronized neural populations were recorded non-invasively as envelope-following responses (EFRs) in young and aged rats. In addition, local field potentials (LFPs) and unit activities were recorded in the inferior colliculus, enabling some measure of input to output transformation within the IC. We found that both EFRs and LFPs were degraded in older animals, even after compensating for hearing thresholds. However, IC unit activity was similar between young and aged rats in many cases using simple measures such as firing rates. We then tested the related question of whether individual sites or populations were able to discriminate between the different VOT stimuli. A template-matching classification model was generated in which single-trial responses were correlated with aggregate trends. IC units were found to discriminate stimuli above chance but still made errors. Integration over a population of units reduced variability and increased performance. It was found that stimulus discrimination was similar for VOT envelopes modulating a noise carrier, but declined in older animals for the original tokens. These results suggest that there may be multiple mechanisms of compensation to maintain neural representations in older animals, including compensation within the IC.

Details

Date:
November 22
Time:
2:00 pm - 3:00 pm

Venue

Sherrington Room
Sherrington Building
Oxford, OX1 3PT United Kingdom
+ Google Map